Influence of XRCC1 Genetic Polymorphisms on Ionizing Radiation-Induced DNA Damage and Repair

Table 1

Reported studies about the association of XRCC1-399 polymorphism and DNA repair capacity.

XRCC1-399 GENOTYPE	IR EXPOSURE	EFFECTS ON DNA REPAIR CAPACITY	REFERENCES
Variant	𝛾-rays	Higher mitotic delay index	Hu et al., 2001 [26]
Variant	X-and 𝛾-rays	Higher MN frequency	Angelini et al., 2005 [29]
Variant	𝛾-rays	No-one on DNA damage values (Comet) Higher background frequency of MN	Rzeszowska et al., 2005 [33]
Variant	𝛾-rays	Higher residual damage (Comet)	Aka et al., 2006 [31]
Gln399Gln	X-rays	Lower DNA damage (Comet)	Cornetta et al., 2006 [27]
Variant	𝛾-rays	No-one on DNA damage values (Comet) and MNCB	Godderis et al., 2006 [32]
Variant	No	Higher basal DNA damage (Comet)	Weng et al., 2009 [28]

Variant= Arg399Gln + Gln399Gln.