Architecture of Y-Family DNA Polymerases Relevant to Translesion DNA Synthesis as Revealed in Structural and Molecular Modeling Studies

Table 1

Dominant dNTP insertions opposite various DNA adducts/lesions by E. coli DNAPs IV and V, and human DNAPs 𝜅 and 𝜂.^†

Lesion	DNAP V	DNAP 𝜂	DNAP IV	DNAP 𝜅
[+ta]-BP-N^2-dG	A/C	A≥G	C	C
AAF-C8-dG	C	C	C/T	C/T
AF-C8-dG	—	—	C	C
TT-CPD	AA	AA	n	n
T(6-4)T	AG	nG	n	n
AP site	A	A	n	A*

^†Dominant dNTP insertion using purified DNAPs, where “n” indicates “no” or low activity, “A*” indicates bypass by an unusual mechanism, and “—” indicates data unavailable. Data, as reviewed in [44].