SOD1 Is Essential for the Viability of DT40 Cells and Nuclear SOD1 Functions as a Guardian of Genomic DNA
Figure 4
Suppression of lethality and increase in SCE frequency in cells depleted of SOD1 by APM (a) Upper panel: growth curves of cells of the indicated genotypes. Cells were cultured with or without 1 g/mL Dox and/or 200 M APM. Lower panel: disappearance of hSOD1 was confirmed by western blotting. (b) SCE frequencies of cells treated with Dox and APM for 0, 120, or 240 hours. A total of 100 metaphase cells was counted in each sample. Bars indicate standard errors.
