Mechanistic Studies with DNA Polymerases Reveal Complex Outcomes following Bypass of DNA Damage

Figure 1

Overview of DNA adducts. The number of DNA adducts formed through interactions with reactive chemicals or ionizing radiation is vast, and more thorough reviews have been performed elsewhere [7]. We have chosen to focus on some of the most thoroughly studied DNA adducts, in terms of how the adduct affects DNA polymerase structure and function. A, abasic sites and 8-oxodG; B, minor groove N²-dG adducts; C, major groove O⁶-dG and N⁶-dA adducts; D, exocyclic dG adducts. Adduct stereospecificity is not shown in structures of of B[a]P DNA adducts.

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