Elevated Levels of DNA Strand Breaks Induced by a Base Analog in the Human Cell Line with the P32T ITPA Variant

<table>Base-analog DNA cycle. Environmental and intrinsic mutagens can damage DNA directly or can damage DNA precursor pools. When cleansing is inefficient, base-analogs are incorporated into DNA. Damaged bases lead to mutations in replication cycles or can be correctly repaired by base excision repair. Intermediates of this repair can lead to mutagenesis, DNA breaks, and chromosome changes.</table>

Journal of Nucleic Acids

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Figure 1

Figure 1: Elevated Levels of DNA Strand Breaks Induced by a Base Analog in the Human Cell Line with the P32T ITPA Variant 