Hierarchical Formation of Fibrillar and Lamellar Self-Assemblies from Guanosine-Based Motifs

<table>Determination of <i>K </i><sub>0</sub> for compound <b>2</b>. <svg height="16.612499" id="M62" style="vertical-align:-5.03984pt" version="1.1" viewbox="0 0 49.599998 16.612499" width="49.599998" xmlns="http://www.w3.org/2000/svg">
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<text transform="matrix(1,0,0,-1,-71.95,63.79)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝑀</tspan>
</text>
<text transform="matrix(1,0,0,-1,-59.38,60.66)">
<tspan style="font-size: 8.75px; " x="0" y="0">𝑤</tspan>
<tspan style="font-size: 8.75px; " x="6.7828002" y="0">,</tspan>
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<tspan style="font-size: 8.75px; " x="0" y="0">a</tspan>
<tspan style="font-size: 8.75px; " x="3.8858881" y="0">p</tspan>
<tspan style="font-size: 8.75px; " x="8.2618876" y="0">p</tspan>
</text>
<text transform="matrix(1,0,0,-1,-37.78,60.66)">
<tspan style="font-size: 8.75px; " x="0" y="0">,</tspan>
<tspan style="font-size: 8.75px; " x="2.188" y="0">𝑖</tspan>
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</g>
</svg> is the molecular weight of the initial monomer starting the association [<a href="/journals/jna/2010/938536/#B23a">59</a>, <a href="/journals/jna/2010/938536/#B23b">60</a>]. The red guiding line shows the experimental points’ sigmoïdal behaviour.  From the straight line, extrapolated for a noncooperative association, it is possible to calculate the mean equilibrium constant of the association <svg height="18.174999" id="M63" style="vertical-align:-3.25793pt" version="1.1" viewbox="0 0 136.64999 18.174999" width="136.64999" xmlns="http://www.w3.org/2000/svg">
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<text transform="matrix(1,0,0,-1,-71.95,60.76)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝐾</tspan>
</text>
<text transform="matrix(1,0,0,-1,-62.42,57.63)">
<tspan style="font-size: 8.75px; " x="0" y="0">0</tspan>
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<text transform="matrix(1,0,0,-1,-54.08,60.76)">
<tspan style="font-size: 12.50px; " x="0" y="0">=</tspan>
<tspan style="font-size: 12.50px; " x="12.040389" y="0">6</tspan>
<tspan style="font-size: 12.50px; " x="18.291889" y="0">.</tspan>
<tspan style="font-size: 12.50px; " x="21.417639" y="0">7</tspan>
<tspan style="font-size: 12.50px; " x="31.832638" y="0">1</tspan>
<tspan style="font-size: 12.50px; " x="38.084137" y="0">0</tspan>
</text>
<text transform="matrix(1,0,0,-1,-9.74,65.93)">
<tspan style="font-size: 8.75px; " x="0" y="0">5</tspan>
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<text transform="matrix(1,0,0,-1,-2.78,60.76)">
<tspan style="font-size: 12.50px; " x="0" y="0">L</tspan>
<tspan style="font-size: 12.50px; " x="9.7148314" y="0">m</tspan>
<tspan style="font-size: 12.50px; " x="19.442165" y="0">o</tspan>
<tspan style="font-size: 12.50px; " x="25.693665" y="0">l</tspan>
</text>
<text transform="matrix(1,0,0,-1,26.4,66.02)">
<tspan style="font-size: 8.75px; " x="0" y="0">−</tspan>
<tspan style="font-size: 8.75px; " x="5.99512" y="0">1</tspan>
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</g>
</g>
</svg>.</table>

Journal of Nucleic Acids

fig8

Figure 8

Figure 8: Hierarchical Formation of Fibrillar and Lamellar Self-Assemblies from Guanosine-Based Motifs 