Regulation of HuR by DNA Damage Response Kinases

Table 1

HuR target mRNAs showing altered expression after DNA damage. Partial list of HuR target mRNAs encoding proteins that change following DNA damage (first column), the region of interaction with HuR (second column), and the genotoxic damage that was shown to affect HuR regulation of the mRNA (third column); “n.r.”: no reported. The HuR kinases linked to the regulation of the mRNAs in the first column are indicated (fourth column).

	Target mRNA after DNA damage	Binding region	DNA damage conditions affecting regulation by HuR	HuR Kinase	References
mRNA stabilization	c-fos	3^UTR	n.r.	n.r.	[−]
	p21	3^UTR	UVC, arsenite, IR	Chk2, p38	[27, 39]
	cyclin A2	3^UTR	H2O2	Chk2, Cdk1	[27, 29]
	cyclin B1	3^UTR	H2O2	n.r.	[40]
	cyclin D1	3^UTR	UVC	Chk2	[27]
	iNOS	3^UTR	n.r.	n.r.	[−]
	VEGF	3^UTR	n.r.	n.r.	[−]
	SIRT1	3^UTR	H2O2	Chk2	[27]
	TNF- 𝛼	3^UTR	n.r.	n.r.	[−]
	bcl-2	3^UTR	n.r.	Cdk1	[28]
	mcl-1	3^UTR	n.r.	Cdk1	[28]
	COX-2	3^UTR	n.r.	PKC, p38	[41, 42]
	uPA	3^UTR	n.r.	n.r.	[−]
	uPAR	3^UTR	n.r.	n.r.	[−]
	IL-3	3^UTR	n.r.	n.r.	[−]
	MKP-1	3^UTR	H2O2	Cdk1	[43]
↑ Translation	p53	3^UTR	UVC	n.r.	[−]
	ProT 𝛼	3^UTR	UVC	Chk2, Cdk1	[29]
	cytochrome c	3^UTR	n.r.	Chk2	[27]
	MKP-1	3^UTR	H2O2	Cdk1	[29]
	HIF-1 𝛼	3^UTR	n.r.	Cdk1	[29]
↓  Translation	p27	5^UTR	n.r.	n.r.	[−]
	IGF-IR	5^UTR	n.r.	n.r.	[−]
	Wnt5a	3^UTR	n.r.	n.r.	[−]
	HuR	3^UTR	n.r.	n.r.	[−]
	c-Myc	3^UTR	n.r.	n.r.	[−]