Novel Indolocarbazole Derivative 12-(α-L-arabinopyranosyl)indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-dione Is a Preferred c-Myc Guanine Quadruplex Ligand

Figure 2

UV absorption spectra of AIC:DNA complexes: (a) AIC:G-c-Myc, (b) AIC:G-tel, and (c) AIC:c-Myc duplex. The concentrations of oligomers Pu18 and d(TTAGGG)4 were 0–2.5 μM (strands) and of c-Myc duplex were 0–3 μM (strands). Curves 1–3 indicate the spectra of free AIC, partially bound AIC and fully bound AIC, respectively: Hanks’ buffer, 𝑡=20°C.

(a)

(b)

(c)