Novel Indolocarbazole Derivative 12-(α-L-arabinopyranosyl)indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-dione Is a Preferred c-Myc Guanine Quadruplex Ligand
Figure 4
Fluorescence of AIC:G-quadruplex complexes. (a) The fluorescence spectra of free AIC in 95% ethanol solution (dashed line), AIC bound to Pu18 G-c-Myc (solid line) and to G-tel (triangles). The intensity of fluorescence was registered after excitation at 320 nm and normalized to 1. The parameter was ~1 for all complexes. Inset: fluorescence of AIC:G-quadruplex complexes depending on . Complexes AIC:G-c-Myc (triangles), AIC:G-tel (circles). (b) Excitation spectra of complexes AIC:G-c-Myc (solid line), AIC:G-tel (triangles), and free AIC in 95% ethanol solution (dashed line). Fluorescence intensity registered at 320 nm was normalized to 1. The numbers of bound AIC molecules per G-c-Myc and G-tel were .
