Novel Indolocarbazole Derivative 12-(α-L-arabinopyranosyl)indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-dione Is a Preferred c-Myc Guanine Quadruplex Ligand

Table 1

Binding parameters of AIC:DNA complexes.

DNA	^[a]𝐾1(×10^−6), M^−1	^[b]𝑛1	𝐾2(×10^−6), M^−1	𝑛2
G-c-Myc	70±10	1	4±1	2
G-tel	6.5±1.0	1	0.33±0.05	1
c-Myc duplex	0.8±0.1	5	—	—

[a]: 𝐾₁, 𝐾₂ are the association constants of AIC:DNA complexes;
[b]: 𝑛₁, 𝑛₂ are the maximal numbers of AIC molecules bound to a particular DNA.