Incorporation of 3-Aminobenzanthrone into 2′-Deoxyoligonucleotides and Its Impact on Duplex Stability

Scheme 1

Synthesis of protected dG(N ²)-3ABA phosphoramidite. (a) 1 M tetrabutylammonium fluoride, THF; (b) triethylamine trihydrofluoride : triethylamine : DMF (4 : 3 : 6); (c) dimethoxytrityl chloride, pyridine; (d) cyanoethoxy diisopropylamino chlorophosphine.