Incorporation of 3-Aminobenzanthrone into 2′-Deoxyoligonucleotides and Its Impact on Duplex Stability

Table 1

Thermodynamic parameters of ABA-modified and unmodified tetradecamer duplexes.

	Δ𝐻^∘25, kcal/mol	Δ𝑆^∘25, cal/mol·K	Δ𝐺^∘25, kcal/mol	Δ𝐺^∘37, kcal/mol	ΔΔG^∘37/lesion, kcal/mol
dG(𝑁^2)-3 ABA duplex	−95±8	−252±24	−21±1.1	−17.9±0.8	−1.5
Control duplex	−98±4	−267±11	−18.2±0.5	−14.9±0.3