Site-Selective Artificial Ribonucleases: Oligonucleotide Conjugates Containing Multiple Imidazole Residues in the Catalytic Domain
Figure 4
Structure-activity correlations found for the conjugates B-Im(N/m). (a) Correlations between the number of imidazole groups in catalytic parts of conjugates and their catalytic activities. Cleaving data corresponds to incubation of the RNA with conjugates 1, 3, 6, 9, and 13 under standard conditions for 1 h. (b) Correlation between the type of anchor groups and catalytic activity of conjugates. Diagram presents data for tetraimidazole-containing conjugates 3, 4a, 5 (B-Im(4/m)) and octaimidazoles-containing conjugates 6, 7, 10 (B-Im(8/m)).
