Use of Nucleic Acid Analogs for the Study of Nucleic Acid Interactions
Figure 4
(a) and (b) Possible conformations of the deoxyadenosine and deoxycytidine derivatives, the nonpolar group stacking conformation (a) and the base pair conformation (b). indicates the phenyl or naphthyl group. The arrow indicates the site of hydrogen bonding with a complementary base. (c) Comparison of the major interaction forces for the stacking of the A/T and C/G base pairs and the stacking of the and . The nonpolar aromatic group in the base pair-mimic nucleosides is indicated in red, and the complementary base is indicated in green.
