Use of Nucleic Acid Analogs for the Study of Nucleic Acid Interactions
Figure 6
(a) The stacking conformation of opposite an abasic site F in the center of a DNA duplex. (b) Hybridization of the DNA strand bearing with a complementary target strand, followed by the formation of the flipped-out conformation. (c) The base flipping conformation induced by in an RNA/DNA duplex. The hybridized RNA strand is cleaved site-selectively at the 5′-side of the phosphodiester bond of the flipped-out ribonucleotide.
