Features of “All LNA” Duplexes Showing a New Type of Nucleic Acid Geometry
Figure 4
Structure of an idealized RNA helix (a) compared to the RNA/LNA hybrid helix derived from the structure with PDB code 1H0Q (b) and compared to an “all LNA” helix derived from the structure with PDB code: 2X2Q (c) as Calladine-Drew plot. To visualize the overall geometry, the helices were extended to 22 base pairs for RNA, to 25 base pairs for the RNA/LNA, and to 28 base pairs for LNA, respectively [9].
