Artificial Specific Binders Directly Recovered from Chemically Modified Nucleic Acid Libraries

Table 1

Comparison of binding affinities in ATP-binding natural/modified nucleic acid aptamers.

Aptamer; type	Chemical structure	Binding affinity 𝐾𝑑	References
Natural RNA		6–8 𝜇M (5 mM Mg^2+); 0.7 𝜇M (20 mM Mg^2+)	[58]
Natural RNA		11 𝜇M (10 mM Mg^2+); 4.8 𝜇M (30 mM Mg^2+)	[59]
Modified RNA		0.45–1.1 𝜇M (6 mM Mg^2+)	[60]
Natural DNA		9 ± 2 𝜇M^2	[61]
Modified DNA		6 ± 1 𝜇M^2	[62]