Dioxaphosphorinane-Constrained Nucleic Acid Dinucleotides as Tools for Structural Tuning of Nucleic Acids

Figure 6

Side and top views of B-type duplex produced by molecular dynamics simulations, the double-helix axes are outlined in green. (a) Unmodified dA₁₀/dT₁₀  ODNref, (b) dA₁₀/dT₄TxTT₄  ODNgm with TxT = (𝑅_𝐶5′, 𝑆_𝑃) α,β-D-CNA TT, or (c) ODNgp with TxT = (𝑆_𝐶5′, 𝑅_𝑃) α,β-D-CNA TT.

(a)

(b)

(c)