Review Article

Chemical Approaches for Structure and Function of RNA in Postgenomic Era

Table 8

Distribution of ESE, 5′ splice sites, branch sites, and 3′ splice sites. The ESE, 5′ splice site, branch site, and 3′ splice site in 4.5S RNA I and Alu elements in FMR1 gene transcript are screened by ESE finder (version 3) [13]. For this comparison, the number of motifs is calculated per 100 nucleotides. The motif patterns in Alu elements are all very much alike and the 4.5S RNA I resembles them. A difference is found in that 5′ splice sites in (+) Alu are more than in (−) Alu and 3′ splice sits are more in (−) Alu than in (+) Alu.

SF2/ASFSC35SRp40SRp55Total5′SSBS3′SS

Novikoff 4.5S RNA I (96 nt)3.653.136.251.0414.07010.42.08
Human FMR1 Alu1(+) (252 nt)4.967.546.351.5920.443.979.135.56
Human FMR1 Alu4(+) (295 nt)4.414.411.692.0312.542.3710.92.37
Human FMR1 Alu5(+) (246 nt)5.695.284.471.2216.664.478.542.44
Human FMR1 Alu7(+) (290 nt)6.212.413.100.3412.063.7910.32.07
Human FRM1 Alu8(+) (288 nt)5.213.473.820.6913.193.478.682.43
(+) Alu Av.5.304.623.891.1714.983.619.512.97
Human FMR1 Alu2(−) (298 nt)3.696.045.031.3416.100.6714.14.70
Human FMR1 Alu3(−) (285 nt)4.927.025.612.1119.663.1613.74.56
Human FMR1 Alu6(−) (290 nt)4.315.524.481.3815.692.7613.54.48
(−) Alu Av.4.316.195.041.6117.152.2013.84.58
Human FMR1 Total Alu(+&−) Av.4.935.214.321.3415.803.0811.13.58