Synthetic Nucleotides as Probes of DNA Polymerase Specificity
Figure 6
Classes of purine/pyrimidine mimics. (a) Skeleton structure of azole heterocyclic carboxamides. Depending on the position of the heteroatoms and their ability to donate or accept hydrogen bonds, these analogs can form base pairs with either a purine or a pyrimidine [91]. (b) General structure of the furo/thieno pyridinones; different heteroatoms in each position give the following compounds: furo[2,3-c]pyridin-7(6H)-one: 7OFP, thieno[2,3-c]pyridin-7(6H)-one: 7OTP, furo[2,3-c]pyridin-7-thiol: 7TFP, furo[3,2-c]pyridin-4(5H)-one: 4OFP, thieno[3,2-c]pyridin-4(5H)-one: 4OTP, furo[3,2-c]pyridin-4-thiol: 4TFP [86, 92].
