Inhibition of HIV Replication by Cyclic and Hairpin PNAs Targeting the HIV-1 TAR RNA Loop

Table 2

IC₅₀ values for TPP-[PNA] conjugates.

TPP-[PNA] conjugates	IC50 (μM)	𝑟^a	𝑚^b
TPP-[PNA 1a]	1.63	0.983	1.15
TPP-[PNA 1b]	1.24	0.953	1.23
TPP-[PNA 1c]	1.94	0.985	1.99
TPP-[PNA 2]	—^c	—	—
TPP-[PNA 3]	—^c	—	—
TPP-[PNA 4]	3.30	0.943	2.65
TPP-[PNA 5]	2.10	0.974	1.39
TPP-[PNA 6]	3.70	0.990	1.18
TPP-[PNA]^dTAR	1.00	0.970	—

^aRepresents linear correlation coefficient of the median effect plot.
^bRepresents measurements of the sigmoidicity of the dose-effect curve.
^cNo inhibition up to 50 μM.
^dObtained from [28].