Functional Annotation of Small Noncoding RNAs Target Genes Provides Evidence for a Deregulated Ubiquitin-Proteasome Pathway in Spinocerebellar Ataxia Type 1

Figure 1

ncRNA expression profiles in the cerebellum and cortex of SCA1 patients and healthy individuals. (a) Heatmap of ncRNA expression profiling comparing the cerebellum of a 61-year-old healthy individual (control) to the cerebellum of an SCA1 patient. SCA1 ncRNAs with increased expression are indicated as cluster 1 and 2. (b) Heatmap of ncRNA expression profiling comparing the frontal cortex of an aging healthy individual (control) to the frontal cortex of an SCA1 patient. SCA1 ncRNAs with increased expression are indicated as cluster 1 and 2. (c) Heatmap of ncRNA expression profiling comparing the cerebellum of a healthy young individual (young) to the cerebellum of an aged healthy subject (old). ncRNAs with increased expression in the aged cerebellum are indicated as cluster 1. (d) Heatmap of ncRNA expression profiling comparing the frontal cortex of a healthy young individual (young) to the frontal cortex of an aged healthy subject (old). ncRNAs with increased expression in the aged cerebellum are indicated as cluster 1.