Table 2: A listing of DNA aptamers reported in the open literature* (up until July 2012) that have been confirmed to bind to small molecule targets. The dissociation constant ( ), a measure of binding affinity, is included as well as the year of aptamer development.

TargetBinding affinity ( )YearReference

Reactive green 1933 μM1992[130]
Adenosine monophosphate and adenosine triphosphate 6 μM1995[131]
L-arginine2.5 mM1995[132]
L-argininamide0.25 mM1995[132]
Anionic porphyrins0.4–4.9 μM1996[88]
Sulforhodamine B190 nM1998[61]
Cellobiose600 nM1998[133]
7,8-dihydro-8-hydroxy-2′-deoxyguanosine270 nM1998[134]
Cholic acid5–67.5 μM2000[135]
Hematoporphyrin1.6 μM2000[136]
L-tyrosinamide4.5 μM2001[137]
Sialyllactose4.9 μM2004[138]
Ethanolamine6–19 nM2005[139]
(R)-thalidomide1 μM2007[49]
Hoechst derivative 7e878 nM2007[140]
17β-estradiol0.13 μM2007[141]
Lys-Arg-Azobenzene-Arg0.33 μM2007[142]
Tetracycline64 nM2008[143]
L and D arginine580–810 μM2008[144]
Daunomycin10 nM2008[145]
Oxytetracycline10 nM2008[54]
Ochratoxin A200 nM2008[26]
Dopamine700 nM2009[146]
8-hydroxy-2′-deoxyguanosine100 nM2009[147]
Diclofenac42.7–166.34 nM2009[148]
(S) and (R)-ibuprofen1.5–5.2 μM2010[50]
Adenosine triphosphate3.7 μM2010[31]
Fumonisin B1 (FB1)100 nM2010[7]
Acetamiprid4.98 μM2011[149]
Kanamycin78.8 nM2011[150]
L-tryptophan1.757 μM2011[151]
Bisphenol A 8.3 nM2011[53]
Ochratoxin A96–293 nM2011[152]
Phenylphosphonic dichloride>50 μM2011[153]
Organophosphorus pesticides (phorate, profenofos, isocarbophos and omethoate)0.8–2.5 μM2012[154]
Polychlorinated biphenyls (PCB77)4.02, 8.32 μM2012[155]
Polychlorinated biphenyls (PCB72 and PCB106)60–100 nM2012[156]
Ampicillin9.4–13.4 nM2012[157]

Only aptamer sequences that have experimentally determined values were included in this table.