miRNA Influences in NRF2 Pathway Interactions within Cancer Models

Figure 2

Overview of ROS-mediated NRF2 activities. A feedback mechanism exists, which provides a fine balance between free circulating cytoplasmic NRF2 and nuclear ARE motif-bound NRF2, with miRNAs such as miR-29-b1 and miR-144 providing direct regulation of NRF2 expression within the cytoplasm.