Table 1: Differential expression of eIF3 subunits in human cancers and notable eIF3-protein interactions.

eIF3 SubunitExpressionCancer associationsProtein interactions

eIF3aBreast, cervix, esophagus, lung & gastric [89, 90]ribonucleotide reductase M2 [91], RARα [92], Raf-1 [93]
eIF3bBreast, bladder & prostate [90]mTOR/S6K1 [94], ICP27 [95], DDX3 [96], NREP [97]
eIF3cColon [98], meningioma [99] & testicular seminomas [100]mTOR/S6K1 [94], MAPK6 [101], CDK2 [102], TARDBP [103], schwannomin [99]
eIF3dColon [104, 105], gastric [70] & mesothelioma [70]hTDAG51 [106], VPg [107]
eIF3eBreast & lung [89, 90]S6K1 [94], DDX3 [96], Rpn5 [108]
eIF3fBreast, colon, melanoma & pancreas [90, 109]mTOR [110], S6K1 [111], HnRNP K [109]
eIF3hBreast, colon, liver & prostate [89, 90]Acetylated HIV-1 IN [112], MGMT [113]