In What Ways Do Synthetic Nucleotides and Natural Base Lesions Alter the Structural Stability of G-Quadruplex Nucleic Acids?

<div>Structures of 6-thioguanine (<b>1</b>); 7-deazaguanine (<b>2</b>); 8-aza-7-deaza-<i>iso</i>guanine (<b>3</b>); pyrene (<b>4</b>) and perylene (<b>5</b>) tethered to C8 of guanine; 6-methyl-isoxanthopterin (<b>6</b>); zebularine or 2-pyrimidinone-riboside (<b>7</b>); and 4-thiouracil (<b>8</b>).</div>

Journal of Nucleic Acids

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Figure 13

Figure 13: In What Ways Do Synthetic Nucleotides and Natural Base Lesions Alter the Structural Stability of G-Quadruplex Nucleic Acids? 