Expression of Genes and Their Polymorphism Influences the Risk of Knee Osteoarthritis

Table 1

Genotype association between SNP in ESR-α gene and knee osteoarthritis.

	All subjects			Women			Men
	Control (%)	Case (%)	OR, (95% CI), value	Control (%); 276	Case (%); 295	OR, (95% CI), value	Control (%) 224	Case (%); 205	OR, (95% CI), value
Genotype
BtgI (rs 2228480)
GG	231 (46.20)	170 (34.00)	1.00, (Ref)	127 (46.01)	94 (31.86)	1.00, (Ref)	104 (46.24)	76 (37.07)	1.00, (Ref)
GA	218 (43.60)	259 (51.8)	1.61, (1.23–2.11),	120 (43.47)	158 (53.55)	1.77, (1.24–2.54),	98 (43.75)	101 (49.26)	1.41, (0.94–2.11), 0.096
AA	51 (10.20)	71 (14.2)	1.89, (1.25–2.85),	29 (10.50)	43 (14.57)	2.00, (1.16–3.44),	22 (09.82)	28 (13.65)	1.74 (0.92–3.27), 0.083
Allele
BtgI (rs 2228480)
G	680 (68.0)	599 (59.9)	1.00, (Ref)	374 (67.75)	346 (58.64)	1.00, (Ref)	306 (68.30)	253 (61.70)	1.00, (Ref)
A	320 (32.0)	401 (40.1)	1.42, (1.18–1.70),	178 (32.24)	244 (41.35)	1.48, (1.16–1.88),	142 (31.69)	157 (38.29)	1.33, (1.00–1.77),

OR, odds ratio; 95% CI, 95% confidence interval; Ref, reference category; p < 0.05 is considered statistically significant.