Journal of Nucleic Acids

Research Article

Expression of Genes and Their Polymorphism Influences the Risk of Knee Osteoarthritis

Table 3

Genotype association between SNP in GDF-5 (BsiE1) gene and knee osteoarthritis (KOA).


	All subjects			Women			Men
	Control (%)	Case (%)	OR, (95% CI), value	Control (%) 276	Case (%) 295	OR, (95% CI), value	Control (%) 224	Case (%) 205	OR, (95% CI), value

Genotype
BsiE1 (rs 143383)
CC	97 (19.40)	75 (15.00)	1.00, (Ref)	58 (21.01)	47 (15.93)	1.00, (Ref)	39 (17.41)	28 (13.65)	1.00, (Ref)
CT	272 (54.4)	226 (45.20)	1.07, (0.75–1.52), 0.686	137 (49.63)	117 (39.66)	1.05, (0.66–1.66), 0.821	135 (60.26)	109 (53.17)	1.12, (0.65–1.94), 0.673
TT	131 (26.2)	199 (39.80)	1.96, (1.35–2.85),	81 (29.34)	131 (44.40)	1.99, (1.24–3.20),	50 (22.32)	68 (33.17)	1.89, (1.03–3.47),

Allele
C	466 (46.6)	376 (37.6)	1.00, (Ref)	253 (45.83)	211 (35.76)	1.00, (Ref)	213 (47.54)	165 (40.24)	1.00, (Ref)
T	534 (53.4)	624 (62.4)	1.44, (1.21–1.73),	299 (54.16)	379 (64.23)	1.52, (1.19–1.92),	235 (52.45)	245 (59.75)	1.34, (1.02–1.76),

OR, odds ratio; 95% CI, 95% confidence interval; Ref, reference category; p < 0.05 is considered statistically significant.