Expression of Genes and Their Polymorphism Influences the Risk of Knee Osteoarthritis

Table 4

Distribution of CALM-1 haplotypes among controls and knee OA cases .

Allele	Control (%)	Case (%)	OR, (95% CI), value	Women			Men
				Control (%)	Case (%)	OR, (95% CI), value	Control (%)	Case (%)	OR, (95% CI), value
CTA	341 (34.1)	320 (32.0)	1.00, (Ref)	167 (30.24)	166 (28.13)	1.00, (Ref)	175 (39.06)	154 (37.56)	1.00, (Ref)
TTC	290 (29.0)	315 (31.5)	1.15, (0.92–1.44), 0.193	155 (28.07)	196 (33.22)	1.27, (0.94–1.71), 0.116	136 (30.35)	119 (29.02)	0.99, (0.71–1.38), 1.000
TTA	208 (20.8)	189 (18.9)	0.96, (0.75–1.24), 0.799	125 (22.64)	119 (20.16)	0.95, (0.68–1.33), 0.797	82 (18.30)	69 (16.82)	0.95, (0.65–1.40), 0.820
CTC	138 (13.8)	120 (12.0)	0.92, (0.69–1.23), 0.604	89 (16.12)	71 (12.03)	0.80, (0.55–1.17), 0.254	49 (10.93)	49 (11.95)	1.13, (0.72–1.78), 0.578
TGC	17 (1.70)	48 (4.8)	3.00, (1.69–5.34), 0.000	11 (1.99)	29 (4.91)	2.65, (1.28–5.48), 0.006	6 (1.33)	19 (4.63)	3.59, (1.40–9.24), 0.004
TGA	2 (0.02)	4 (0.04)	2.13, (0.38–11.71), 0.373	2 (0.36)	4 (0.06)	2.01, (0.36–11.13), 0.414
CGA	3 (0.03)	2 (0.02)	0.71, (0.11–4.27), 0.707	3 (0.54)	2 (0.03)	0.67, (0.11–4.06), 0.661
CGC	1 (0.01)	2 (0.02)	2.13, (0.19–23.61), 0.527	1 (0.18)	2 (0.03)	2.01, (0.18–22.40), 0.561

OR, odds ratio; 95% CI, 95% confidence interval; Ref, reference category; is considered statistically significant.