Table of Contents Author Guidelines Submit a Manuscript
Table of Contents Alerts

To receive news and publication updates for Journal of Nucleic Acids, enter your email address in the box below.

Journal of Nucleic Acids
Volume 2017 (2017), Article ID 8154646, 12 pages
https://doi.org/10.1155/2017/8154646
Research Article

Overexpression of PCNA Attenuates Oxidative Stress-Caused Delay of Gap-Filling during Repair of UV-Induced DNA Damage

Yi-Chih Tsai, Yi-Hsiang Wang, and Yin-Chang Liu

Institute of Molecular Medicine, National Tsing Hua University, Hsinchu 30013, Taiwan

Correspondence should be addressed to Yin-Chang Liu; wt.ude.uhtn.efil@uilcy

Received 4 August 2016; Revised 12 October 2016; Accepted 15 November 2016; Published 1 January 2017

Academic Editor: Tapas Hazra

Copyright © 2017 Yi-Chih Tsai et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. De Boer and J. H. J. Hoeijmakers, “Nucleotide excision repair and human syndromes,” Carcinogenesis, vol. 21, no. 3, pp. 453–460, 2000. View at Publisher · View at Google Scholar · View at Scopus
  2. E. C. Friedberg, DNA Repair and Mutagenesis, ASM Press, Washington, DC, USA, 2nd edition, 2006.
  3. M.-K. Chen, Y.-C. Tsai, P.-Y. Li et al., “Delay of gap filling during nucleotide excision repair by base excision repair: the concept of competition exemplified by the effect of propolis,” Toxicological Sciences, vol. 122, no. 2, pp. 339–348, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. A. R. S. Collins, S. L. Schor, and R. T. Johnson, “The inhibition of repair in UV irradiated human cells,” Mutation Research, vol. 42, no. 3, pp. 413–432, 1977. View at Publisher · View at Google Scholar · View at Scopus
  5. Y. Fujiwara, “Postreplication repair of ultraviolet damage to DNA, DNA chain elongation, and effects of metabolic inhibitors in mouse L cells,” Biophysical Journal, vol. 15, no. 5, pp. 403–415, 1975. View at Publisher · View at Google Scholar · View at Scopus
  6. C. M. Gedik, S. W. B. Ewen, and A. R. Collins, “Single-cell gel electrophoresis applied to the analysis of UV-c damage and its repair in human cells,” International Journal of Radiation Biology, vol. 62, no. 3, pp. 313–320, 1992. View at Publisher · View at Google Scholar · View at Scopus
  7. S. Lynn, H.-T. Lai, J.-R. Gurr, and K. Y. Jan, “Arsenite retards DNA break rejoining by inhibiting DNA ligation,” Mutagenesis, vol. 12, no. 5, pp. 353–358, 1997. View at Publisher · View at Google Scholar · View at Scopus
  8. P.-Y. Li, Y.-C. Chang, B.-S. Tzang, C.-C. Chen, and Y.-C. Liu, “Antibiotic amoxicillin induces DNA lesions in mammalian cells possibly via the reactive oxygen species,” Mutation Research/Genetic Toxicology and Environmental Mutagenesis, vol. 629, no. 2, pp. 133–139, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. A. R. Collins, “The comet assay for DNA damage and repair: principles, applications, and limitations,” Applied Biochemistry and Biotechnology—Part B Molecular Biotechnology, vol. 26, no. 3, pp. 249–261, 2004. View at Publisher · View at Google Scholar · View at Scopus
  10. T. K. Hazra, A. Das, S. Das, S. Choudhury, Y. W. Kow, and R. Roy, “Oxidative DNA damage repair in mammalian cells: a new perspective,” DNA Repair, vol. 6, no. 4, pp. 470–480, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. P. Fortini, B. Pascucci, E. Parlanti, M. D'Errico, V. Simonelli, and E. Dogliotti, “The base excision repair: mechanisms and its relevance for cancer susceptibility,” Biochimie, vol. 85, no. 11, pp. 1053–1071, 2003. View at Publisher · View at Google Scholar · View at Scopus
  12. A. B. Robertson, A. Klungland, T. Rognes, and I. Leiros, “DNA repair in mammalian cells: base excision repair: the long and short of it,” Cellular and Molecular Life Sciences, vol. 66, no. 6, pp. 981–993, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. J. Kuriyan and M. O'Donnell, “Sliding clamps of DNA polymerases,” Journal of Molecular Biology, vol. 234, no. 4, pp. 915–925, 1993. View at Publisher · View at Google Scholar · View at Scopus
  14. I. Stoimenov and T. Helleday, “PCNA on the crossroad of cancer,” Biochemical Society Transactions, vol. 37, no. 3, pp. 605–613, 2009. View at Publisher · View at Google Scholar · View at Scopus
  15. P. Burkovics, I. Hajdú, V. Szukacsov, I. Unk, and L. Haracska, “Role of PCNA-dependent stimulation of 3′-phosphodiesterase and 3′–5′ exonuclease activities of human Ape2 in repair of oxidative DNA damage,” Nucleic Acids Research, vol. 37, no. 13, pp. 4247–4255, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. H. Dou, C. A. Theriot, A. Das et al., “Interaction of the human DNA glycosylase NEIL1 with proliferating cell nuclear antigen: the potential for replication-associated repair of oxidized bases in mammalian genomes,” Journal of Biological Chemistry, vol. 283, no. 6, pp. 3130–3140, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. S. N. Naryzhny, “Proliferating cell nuclear antigen: a proteomics view,” Cellular and Molecular Life Sciences, vol. 65, no. 23, pp. 3789–3808, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. A. D. Giglio, S. O'brien, R. J. Ford et al., “Proliferating cell nuclear antigen (PCNA) expression in chronic lymphocytic leukemia (CLL),” Leukemia and Lymphoma, vol. 10, no. 4-5, pp. 265–271, 1993. View at Publisher · View at Google Scholar · View at Scopus
  19. Y.-C. Liu, R. L. Marraccino, P. C. Keng et al., “Requirement for proliferating cell nuclear antigen expression during stages of the Chinese hamster ovary cell cycle,” Biochemistry, vol. 28, no. 7, pp. 2967–2974, 1989. View at Publisher · View at Google Scholar · View at Scopus
  20. N. P. Singh, M. T. McCoy, R. R. Tice, and E. L. Schneider, “A simple technique for quantitation of low levels of DNA damage in individual cells,” Experimental Cell Research, vol. 175, no. 1, pp. 184–191, 1988. View at Publisher · View at Google Scholar
  21. Y.-C. Chang, K.-Y. Jan, C.-A. Cheng, C.-B. Liao, and Y.-C. Liu, “Direct involvement of the tumor suppressor p53 in nucleotide excision repair,” DNA Repair, vol. 7, no. 5, pp. 751–761, 2008. View at Publisher · View at Google Scholar · View at Scopus
  22. D. J. Gordon, A. E. Milner, R. P. Beaney, D. J. Grdina, and A. T. M. Vaughan, “The increase in radioresistance of Chinese hamster cells cultured as spheroids is correlated to changes in nuclear morphology,” Radiation Research, vol. 121, no. 2, pp. 175–179, 1990. View at Publisher · View at Google Scholar · View at Scopus
  23. S. Inturi, N. Tewari-Singh, M. Gu et al., “Mechanisms of sulfur mustard analog 2-chloroethyl ethyl sulfide-induced DNA damage in skin epidermal cells and fibroblasts,” Free Radical Biology and Medicine, vol. 51, no. 12, pp. 2272–2280, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. R. P. Soultanakis, R. J. Melamede, I. A. Bespalov et al., “Fluorescence detection of 8-oxoguanine in nuclear and mitochondrial DNA of cultured cells using a recombinant Fab and confocal scanning laser microscopy,” Free Radical Biology & Medicine, vol. 28, no. 6, pp. 987–998, 2000. View at Google Scholar
  25. C. A. Hoy, L. C. Seamer, and R. T. Schimke, “Thermal denaturation of DNA for immunochemical staining of incorporated bromodeoxyuridine (BrdUrd): critical factors that affect the amount of fluorescence and the shape of BrdUrd/DNA histogram,” Cytometry, vol. 10, no. 6, pp. 718–725, 1989. View at Publisher · View at Google Scholar · View at Scopus
  26. H. Li, T.-W. Chang, Y.-C. Tsai et al., “Colcemid inhibits the rejoining of the nucleotide excision repair of UVC-induced DNA damages in Chinese hamster ovary cells,” Mutation Research, vol. 588, no. 2, pp. 118–128, 2005. View at Publisher · View at Google Scholar · View at Scopus
  27. B. R. Chapados, D. J. Hosfield, S. Han et al., “Structural Basis for FEN-1 Substrate Specificity and PCNA-Mediated Activation in DNA Replication and Repair,” Cell, vol. 116, no. 1, pp. 39–50, 2004. View at Publisher · View at Google Scholar · View at Scopus
  28. X. V. Gomes and P. M. J. Burgers, “Two modes of FEN1 binding to PCNA regulated by DNA,” The EMBO Journal, vol. 19, no. 14, pp. 3811–3821, 2000. View at Publisher · View at Google Scholar · View at Scopus
  29. S. Vijayakumar, B. R. Chapados, K. H. Schmidt, R. D. Kolodner, J. A. Tainer, and A. E. Tomkinson, “The C-terminal domain of yeast PCNA is required for physical and functional interactions with Cdc9 DNA ligase,” Nucleic Acids Research, vol. 35, no. 5, pp. 1624–1637, 2007. View at Publisher · View at Google Scholar · View at Scopus
  30. J. Fan, M. Otterlei, H.-K. Wong, A. E. Tomkinson, and D. M. Wilson III, “XRCC1 co-localizes and physically interacts with PCNA,” Nucleic Acids Research, vol. 32, no. 7, pp. 2193–2201, 2004. View at Publisher · View at Google Scholar · View at Scopus
  31. Z. Tan, M. Wortman, K. L. Dillehay et al., “Small-molecule targeting of proliferating cell nuclear antigen chromatin association inhibits tumor cell growth,” Molecular Pharmacology, vol. 81, no. 6, pp. 811–819, 2012. View at Publisher · View at Google Scholar · View at Scopus
  32. A. Inoue, S. Kikuchi, A. Hishiki et al., “A small molecule inhibitor of monoubiquitinated proliferating cell nuclear antigen (PCNA) inhibits repair of interstrand DNA cross-link, enhances DNA double strand break, and sensitizes cancer cells to cisplatin,” Journal of Biological Chemistry, vol. 289, no. 10, pp. 7109–7120, 2014. View at Publisher · View at Google Scholar · View at Scopus