Effects of 5-Hydroxymethylcytosine Epigenetic Modification on the Stability and Molecular Recognition of VEGF i-Motif and G-Quadruplex Structures

Table 6

Thermal stability of VEGF G4 modification sequences at lower concentrations of cosolvents. 30% ACN increased thermal profiles of each modification as compared to their respective controls in 10 mM KCl. No marked changes in enthalpy were observed. Error bars are omitted for clarity and are <10% of the values shown; ND = not determinable.

	(°C)	(kcal/mol)	(°C)	(kcal/mol)	(°C)	(kcal/mol)	(°C)	(kcal/mol)
Control	62	21	50	12	ND	ND	73	16
10 mM KCl	67	29	68	29	68	27	67	25
10 mM KCl + 30% ACN	83	33	80	24	84	24	80	20