Journal of Nucleic Acids



Lead Editor

1University College London, London, UK

2University of St. Thomas, St Paul, USA



Guanine rich DNA and RNA sequences can self-assemble to form noncanonical secondary and tertiary structures termed G-quadruplexes (GQs). Since the first report of guanine-quartet by Gellert et al. in 1962, the interest and research in these noncanonical nucleic acid architectures have increased by manyfold. Potential quadruplex-forming sequences (PQS) are distributed throughout the human genome especially at the gene-controlling sites like promoters. The biological role of quadruplexes is yet to be validated, but due to presence of PQS at gene-controlling sites, there is particular interest in them as targets for therapeutic intervention. The structures of many quadruplexes by synthetic nucleotides have been elucidated by X-ray and NMR methods.

This special issue aims to cover the recent developments in the quadruplex research. We aim to cover diverse topics ranging from structure, formation and stability, exploration of biological role to potential role in biotechnology of quadruplexes. The issue will be of special interest to readers that want to know the formation and role of noncanonical nucleic acid architectures.

Potential topics include but are not limited to the following:

  • Milestones in G-quadruplex research
  • Functional assemblies made from supramolecular G-quadruplexes
  • Thermodynamics of G-quadruplexes
  • G-quadruplex probed at the single molecular level by force-based methods
  • Characterization of G-quadruplexes by CD and fluorescence spectroscopy
  • Synthesis and properties of oligonucleotides forming G-quadruplexes
  • Solution dynamics and structure of G-quadruplexes studied by dynamic light scattering
  • Fundamentals and applications of the geometric formalism of quadruplex folding
  • Computational methods for studying G-quadruplex nucleic acids
  • G-quadruplex folding
  • Biological functions of G-quadruplexes
  • Quadruplex nucleic acids as a therapeutic target
  • Screening for quadruplex binding ligands
  • Recognition of G-quadruplexes by metal complexes
  • Catalytic G-quadruplexes
  • Conductive behavior of G4-DNA-silver nanoparticle structures


  • Special Issue
  • - Volume 2018
  • - Article ID 1079191
  • - Editorial

G-Quadruplexes (GQU)

Shozeb Haider | Gary N. Parkinson | Thomas C. Marsh
  • Special Issue
  • - Volume 2018
  • - Article ID 5307106
  • - Review Article

Electrochemical and AFM Characterization of G-Quadruplex Electrochemical Biosensors and Applications

Ana-Maria Chiorcea-Paquim | Ramon Eritja | Ana Maria Oliveira-Brett
  • Special Issue
  • - Volume 2017
  • - Article ID 6513720
  • - Research Article

Putative HIV and SIV G-Quadruplex Sequences in Coding and Noncoding Regions Can Form G-Quadruplexes

Petra Krafčíková | Erika Demkovičová | ... | Viktor Víglaský
  • Special Issue
  • - Volume 2017
  • - Article ID 9170371
  • - Research Article

Telomeric G-Quadruplexes: From Human to Tetrahymena Repeats

Erika Demkovičová | Ľuboš Bauer | ... | Viktor Víglaský
  • Special Issue
  • - Volume 2017
  • - Article ID 9675348
  • - Review Article

On Characterizing the Interactions between Proteins and Guanine Quadruplex Structures of Nucleic Acids

Ewan K. S. McRae | Evan P. Booy | ... | Sean A. McKenna
  • Special Issue
  • - Volume 2017
  • - Article ID 6798759
  • - Research Article

On the Helical Structure of Guanosine 5′-Monophosphate Formed at pH 5: Is It Left- or Right-Handed?

Gang Wu | Irene C. M. Kwan | ... | Eric Ye
  • Special Issue
  • - Volume 2017
  • - Article ID 1641845
  • - Review Article

In What Ways Do Synthetic Nucleotides and Natural Base Lesions Alter the Structural Stability of G-Quadruplex Nucleic Acids?

Janos Sagi
Journal of Nucleic Acids
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