Table of Contents
Journal of Neurodegenerative Diseases
Volume 2013, Article ID 407903, 12 pages
Research Article

Increasing Membrane Cholesterol Level Increases the Amyloidogenic Peptide by Enhancing the Expression of Phospholipase C

1Department of Physiology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon 440-746, Republic of Korea
2Department of Pathology, Columbia University Medical Center, New York, NY 10032, USA

Received 6 November 2012; Accepted 9 December 2012

Academic Editor: Yasuji Matsuoka

Copyright © 2013 Yoon Sun Chun et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary Figure 1: Water-soluble cholesterol increases membrane cholesterol levels.

Supplementary Figure 2: The expression level of PLCβ1 was increased by cholesterol augmentation.

Supplementary Figure 3: Augmentation of membrane cholesterol levels did not increase the expression levels of PLCβ2, PLCβ4, and PLCγ1 from APP-transfected HeLa cells.

  1. Supplementary Figures