Journal of Neurodegenerative Diseases / 2013 / Article / Tab 1

Review Article

Sleep-Wake Cycle and Daytime Sleepiness in the Myotonic Dystrophies

Table 1

Sleep disorders and DM1.

Sleep disorderSleep findingsReferences

Romigi et al., 2011 [10]; Yu et al., 2011 [9];
Cirignotta et al., 1987 [29]
Pincherle et al., 2012 [56]

Idiopathic hypersomniaLowCSF orexin A
Normal CSF Orexin A
Loss of 5HT neurons of DRN
Martinez-Rodríguez et al., 2003 [13]
Ciafaloni et al., 2008 [32]
Ono et al., 1998 [12]
Manni et al., 1991 [33]

Restless legs syndrome & PLMSPLMS > 5/h in 38% childhood-onset DM1 uncontrolled PSG study
PLMS > 5/h in 61.1% adult-onset DM1 (controlled)
Quera Salva, 2006 [20]
Romigi et al., 2011 [10]
Ciafaloni et al. 2008 [32]; Yu et al., 2011 [9]

REM sleep dysregulationNarcoleptic-likephenotypeMartinez-Rodríguez et al., 2003 [13]
SOREMPs and low MSL (MSLT)Martinez-Rodríguez et al., 2003 [13]; Ciafaloni et al., 2008 [32]; Laberge et al., 2009 [14, 27]; Yu et al., 2011 [9];
Higher REM densityYu et al, 2011 [9]

OSA: obstructive sleep apnea; CSA: central sleep apnea; CSA-CSR: central sleep apnea and cheyne_stokes respiration; CSF: cerebrospinal fluid; 5HT serotonine; DRN: dorsal raphe nucleus; EDS: excessive daytime somnolence; PLMS: periodic limb movement of sleep; PLMW: periodic limb movement of wake; SOREMPs: sleep onset REM periods.

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