Differential Changes in Postsynaptic Density Proteins in Postmortem Huntington’s Disease and Parkinson’s Disease Human Brains

Figure 2

SAP97 expression in human HD and PD hippocampus and striatum. (a) Significant increases in SAP97 expression in the post-mortem human hippocampus in HD and PD patients. The significant increase in SAP97 expression occurs in all hippocampal regions examined: DG, area CA3, and area CA1. ^∗𝑃<0.05, ^∗∗𝑃<0.005. (b) No significant changes in SAP97 expression were observed in HD or PD striatum in either the caudate nucleus (CN) or the putamen (Put). (c) Representative images of SAP97 immunostaining in the dentate gyrus and CA3 and CA1 hippocampal regions. (d) Representative striatal images of SAP97 immunostaining in the putamen and caudate nucleus. Scale bar 25 𝜇m for (c) and (d). (e) High power example image of SAP97 immunolabeling, showing the expected somatic and dendritic localisations.

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