An Intrabody Drug (rAAV6-INT41) Reduces the Binding of N-Terminal Huntingtin Fragment(s) to DNA to Basal Levels in PC12 Cells and Delays Cognitive Loss in the R6/2 Animal Model

Figure 5

INT41 reduced Htt aggregate formation in R6/2 animal model: aggregates in coronal sections of female mice were measured in 4 fields, binned by size, and analyzed for the frequency of sized aggregates as indicated. Analysis of variance on 4113 data points for 0-1 m size category was 0.085 comparing striatal fields, as described in Section 2, from 5 GFP and 6 INT41 mice.