Table of Contents
Journal of Neurodegenerative Diseases
Volume 2017, Article ID 9540609, 4 pages
Research Article

Visual Evoked Potentials in Primary Open Angle Glaucoma

1Department of Physiology, Kathmandu University School of Medical Sciences, Dhulikhel, Kavre, Nepal
2Department of Basic and Clinical Physiology, BP Koirala Institute of Health Sciences, Dharan, Sunsari, Nepal
3Department of Ophthalmology, BP Koirala Institute of Health Sciences, Dharan, Sunsari, Nepal

Correspondence should be addressed to Mukesh Kumar Jha; moc.liamg@pnj.hsekumahj

Received 2 February 2017; Revised 15 June 2017; Accepted 22 June 2017; Published 20 July 2017

Academic Editor: Chaur-Jong Hu

Copyright © 2017 Mukesh Kumar Jha et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background and Aims. Visual evoked potentials (VEPs) assess the integrity of the visual pathways from the optic nerve to the occipital cortex. Optic disc cupping and visual field loss have been associated with prolongation of latency of VEP in primary open angle glaucoma (POAG). Methods. Pattern reversal and flash VEP tests were done in consenting 20 primary open angle glaucoma eyes and 40 normal control eyes. Results. In POAG cases, the refractive error [ versus , D, ], cup-disc ratio in percent [ versus , ], intraocular pressure [ versus , mmHg, ], and automated visual field pattern standard deviation [ versus , dB, ] were significantly more than in control. The visual acuity [ versus , ], foveal visual sensitivity [ versus , dB, ], and automated visual field mean deviation [− versus , dB, ] were significantly less in cases than in control. Among VEP variables, pattern reversal latency N145 [ versus , ms, ], flash amplitude N75 [ versus , μV, ], and flash amplitude N145 [ versus , μV, ] were increased in cases. The pattern reversal amplitude N75 [ versus , μV, ], amplitude P100 [ versus , μV, ], and amplitude N145 [ versus , μV, ] were decreased in cases. Conclusions. POAG caused glaucomatous damage to optic pathway.