Table of Contents
Journal of Nanoparticles
Volume 2013, Article ID 780786, 6 pages
Research Article

Ecofriendly and Facile One-Pot Multicomponent Synthesis of Thiopyrimidines under Microwave Irradiation

1Department of Medicinal Chemistry, Roland Institute of Pharmaceutical Sciences, Khodasingi, Berhampur 760 010, India
2School of Pharmaceutical Education & Research, Berhampur University, Berhampur 760 007, Odisha, India

Received 31 December 2012; Revised 20 February 2013; Accepted 25 February 2013

Academic Editor: Alexander Kauffmann

Copyright © 2013 Biswa Mohan Sahoo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A rapid, improved, and ecofriendly synthesis of thiopyrimidines is carried out via one-pot multicomponent reaction of ethylcyanoacetate, substituted benzaldehydes, and thiourea in presence of ethanolic K2CO3 using microwave irradiation heating method. Excellent yields, shorter reaction time, and easy workup are the major advantageous features of this green protocol. So the application of multicomponent reactions involves the combination of multiple starting materials with different functional groups leading to the highly efficient and environmentally friendly construction of multifunctional drug molecules. The structures of the newly synthesized products were assigned on the basis of IR and 1HNMR spectral data.