Table of Contents
Journal of Nanoparticles
Volume 2014 (2014), Article ID 278761, 9 pages
http://dx.doi.org/10.1155/2014/278761
Research Article

Magnetic Fluid Hyperthermia of Rodent Tumors Using Manganese Perovskite Nanoparticles

1R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, Vasilkovskaya Street 45, Kiev 03022, Ukraine
2V.I. Vernadsky Institute of General and Inorganic Chemistry, National Academy of Sciences of Ukraine, Prospekt Palladina 32/34, Kiev 03142, Ukraine
3Institute of Electrodynamic, National Academy of Sciences of Ukraine, Prospekt Pobedy 56, Kiev 03057, Ukraine

Received 30 May 2014; Accepted 18 July 2014; Published 14 August 2014

Academic Editor: Fabien Grasset

Copyright © 2014 Larissa Bubnovskaya et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose. To test the antitumor activity of magnetic fluid (MF) on the basis of substituted lanthanum-strontium manganite nanoparticles combined with alternating magnetic field (AMF) in experiments with transplanted tumors. Materials and Methods. MF with a size of nanoparticles of 30–40 nm in aqueous agarose solution was investigated. The ability of MF to heat tumor under AMF (300 kHz, 7.7 kA/m) was tested in vivo with rodent tumors (Guerin carcinoma, Walker-256 carcinosarcoma, and Lewis lung carcinoma (3LL)). Results. Single administration of MF into the tumor at a dose of 150 mg/kg (rats) or 200 mg/kg (mice) followed by AMF within 20–30 min (treatment was repeated 3-4-fold) has resulted in the complete regression of tumor in the 35% of rats and 57% of mice. Administration of MF alone or action of AMF alone has not resulted in tumor growth inhibition. The chemomodifying effect of nanohyperthermia was determined, in particular for cisplatinum: thermal enhancement ratio was 2.0. It was also observed that nanohyperthermia has resulted in the absence of 3LL metastases in 43% of mice. Conclusions. MF on the basis of lanthanum-strontium manganite may be considered as an effective inductor of tumor local hyperthermia.