Table of Contents
Journal of Nanoscience
Volume 2013, Article ID 940719, 8 pages
http://dx.doi.org/10.1155/2013/940719
Research Article

Therapeutic Potential of Biologically Reduced Silver Nanoparticles from Actinomycete Cultures

1Department of Biotechnology, Noorul Islam College of Arts and Sciences, Kumaracoil, Kanyakumari District, Tamil Nadu, India
2Department of Nanotechnology, Noorul Islam Centre for Higher Education, Noorul Islam University, Kumaracoil, Kanyakumari District, Tamil Nadu, India

Received 29 April 2013; Revised 16 August 2013; Accepted 24 August 2013

Academic Editor: Kalimuthu Kalishwaralal

Copyright © 2013 M. K. Sukanya et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Silver nanoparticles are applied in nanomedicine from time immemorial and are still used as powerful antibiotic and anti-inflammatory agents. Antibiotics produced by actinomycetes are popular in almost all the therapeutic measures, and this study has proven that these microbes are also helpful in the biosynthesis of silver nanoparticles with good surface and size characteristics. Silver can be synthesized by various chemical methodologies, and most of them have turned to be toxic. This study has been successful in isolating the microbes from polluted environment, and subjecting them to the reduction of silver nanoparticles, characterizing the nanoparticles by UV spectrophotometry and transmission electron microscopy. The nanoparticles produced were tested for their antimicrobial property, and the zone of inhibition was greater than those produced by their chemically synthesized counterparts. Actinomycetes, helpful in bioremediating heavy metals, are useful for the production of metallic nanoparticles. The biosynthesized silver nanoparticles loaded with antibiotics prove to be better in killing the pathogens and have opened up new areas for developing nanobiotechnological research based on microbial applications.