Formulation of a Novel Nanoemulsion System for Enhanced Solubility of a Sparingly Water Soluble Antibiotic, Clarithromycin

Table 4

ANOVA for response surface quadratic model.

Source	Sum of squares	df	Mean square	𝐹 value	𝑃 value
					Prob >𝐹
Model	794.6701	9	88.29667	11.81452	0.0003
𝐴: olive oil	528.3974	1	528.3974	70.70214	<0.0001
𝐵: polysorbate 80	132.4818	1	132.4818	17.72671	0.0018
𝐶: PVA	43.88657	1	43.88657	5.872235	0.0359
𝐴𝐵	0.452036	1	0.452036	0.060485	0.8107
𝐴𝐶	8.555034	1	8.555034	1.144705	0.3098
𝐵𝐶	0.094241	1	0.094241	0.01261	0.9128
𝐴^2	1.474551	1	1.474551	0.197302	0.6664
𝐵^2	46.06179	1	46.06179	6.163291	0.0324
𝐶^2	36.40223	1	36.40223	4.870796	0.0518
Residual	74.7357	10	7.47357
Lack of fit	74.7357	5	14.94714