Table of Contents
Journal of Oral Diseases
Volume 2016, Article ID 7824321, 11 pages
http://dx.doi.org/10.1155/2016/7824321
Review Article

Relationship between Chronic Periodontitis and Erectile Dysfunction: A Narrative Review

1Division of Periodontics, Columbia University College of Dental Medicine, 622 W 168th Street, New York, NY 10032, USA
2Department of Preventive and Community Dentistry, University of Iowa College of Dentistry, 801 Newton Road, Iowa City, IA 52242, USA
3Columbia University College of Dental Medicine, 622 W 168th Street, New York, NY 10032, USA
4Department of Pediatric Dentistry, Henry M. Goldman School of Dental Medicine, Boston University, 100 E. Newton Street, Boston, MA 02118, USA

Received 9 January 2016; Revised 13 February 2016; Accepted 23 February 2016

Academic Editor: Atsushi Saito

Copyright © 2016 Jaffer A. Shariff et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. “Parameters of care. American Academy of Periodontology,” Journal of Periodontology, vol. 71, no. 5, supplement, pp. 1-2, 847–883, 2000.
  2. B. L. Pihlstrom, B. S. Michalowicz, and N. W. Johnson, “Periodontal diseases,” The Lancet, vol. 366, no. 9499, pp. 1809–1820, 2005. View at Publisher · View at Google Scholar · View at Scopus
  3. J. Durham, H. M. Fraser, G. I. McCracken, K. M. Stone, M. T. John, and P. M. Preshaw, “Impact of periodontitis on oral health-related quality of life,” Journal of Dentistry, vol. 41, no. 4, pp. 370–376, 2013. View at Publisher · View at Google Scholar · View at Scopus
  4. J. Cunha-Cruz, P. P. Hujoel, and N. R. Kressin, “Oral health-related quality of life of periodontal patients,” Journal of Periodontal Research, vol. 42, no. 2, pp. 169–176, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. S. K. S. Ng and W. K. Leung, “Oral health-related quality of life and periodontal status,” Community Dentistry and Oral Epidemiology, vol. 34, no. 2, pp. 114–122, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. P. E. Petersen, “The World Oral Health Report 2003: continuous improvement of oral health in the 21st century—the approach of the WHO Global Oral Health Programme,” Community Dentistry and Oral Epidemiology, vol. 31, supplement 1, pp. 3–24, 2003. View at Publisher · View at Google Scholar
  7. P. I. Eke, B. A. Dye, L. Wei et al., “Update on prevalence of periodontitis in adults in the United States: NHANES 2009 to 2012,” Journal of Periodontology, vol. 86, no. 5, pp. 611–622, 2015. View at Publisher · View at Google Scholar
  8. Anonymous, “NIH consensus conference. Impotence. NIH consensus development panel on impotence,” The Journal of the American Medical Association, vol. 270, no. 1, pp. 83–90, 1993. View at Publisher · View at Google Scholar
  9. M. S. Litwin, R. J. Nied, and N. Dhanani, “Health-related quality of life in men with erectile dysfunction,” Journal of General Internal Medicine, vol. 13, no. 3, pp. 159–166, 1998. View at Publisher · View at Google Scholar · View at Scopus
  10. S. Gheorghiu, M. Godschalk, A. Gentili, and T. Mulligan, “Quality of life in patients using self-administered intracavernous injections of prostaglandin E1 for erectile dysfunction,” The Journal of Urology, vol. 156, no. 1, pp. 80–81, 1996. View at Publisher · View at Google Scholar · View at Scopus
  11. E. O. Laumann, A. Paik, and R. C. Rosen, “Sexual dysfunction in the United States: prevalence and predictors,” The Journal of the American Medical Association, vol. 281, no. 6, pp. 537–544, 1999. View at Publisher · View at Google Scholar · View at Scopus
  12. J. J. Heidelbaugh, “Management of erectile dysfunction,” American Family Physician, vol. 81, no. 3, pp. 305–312, 2010. View at Google Scholar · View at Scopus
  13. H. Solomon, J. W. Man, and G. Jackson, “Erectile dysfunction and the cardiovascular patient: endothelial dysfunction is the common denominator,” Heart, vol. 89, no. 3, pp. 251–253, 2003. View at Publisher · View at Google Scholar · View at Scopus
  14. F. S. Carneiro, R. C. Webb, and R. C. Tostes, “Emerging role for TNF-α in erectile dysfunction,” Journal of Sexual Medicine, vol. 7, no. 12, pp. 3823–3834, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. A. Eltas, F. Oguz, M. O. Uslu, and E. Akdemir, “The effect of periodontal treatment in improving erectile dysfunction: a randomized controlled trial,” Journal of Clinical Periodontology, vol. 40, no. 2, pp. 148–154, 2013. View at Publisher · View at Google Scholar · View at Scopus
  16. P. Montorsi, F. Montorsi, and C. C. Schulman, “Is erectile dysfunction the ‘tip of the lceberg’ of a systemic vascular disorder?” European Urology, vol. 44, no. 3, pp. 352–354, 2003. View at Publisher · View at Google Scholar · View at Scopus
  17. M. Kirby, G. Jackson, and U. Simonsen, “Endothelial dysfunction links erectile dysfunction to heart disease,” International Journal of Clinical Practice, vol. 59, no. 2, pp. 225–229, 2005. View at Publisher · View at Google Scholar · View at Scopus
  18. I. A. Aytaç, J. B. McKinlay, and R. J. Krane, “The likely worldwide increase in erectile dysfunction between 1995 and 2025 and some possible policy consequences,” BJU International, vol. 84, no. 1, pp. 50–56, 1999. View at Publisher · View at Google Scholar · View at Scopus
  19. H. A. Feldman, I. Goldstein, D. G. Hatzichristou, R. J. Krane, and J. B. McKinlay, “Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study,” The Journal of Urology, vol. 151, no. 1, pp. 54–61, 1994. View at Google Scholar · View at Scopus
  20. E. Selvin, A. L. Burnett, and E. A. Platz, “Prevalence and risk factors for erectile dysfunction in the US,” The American Journal of Medicine, vol. 120, no. 2, pp. 151–157, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. C. B. Johannes, A. B. Araujo, H. A. Feldman, C. A. Derby, K. P. Kleinman, and J. B. McKinlay, “Incidence of erectile dysfunction in men 40 to 69 years old: longitudinal results from the Massachusetts male aging study,” The Journal of Urology, vol. 163, no. 2, pp. 460–463, 2000. View at Publisher · View at Google Scholar · View at Scopus
  22. B. L. Mealey and P. R. Klokkevold, “Periodontal medicine,” in Carranza's Clinical Periodontology, M. G. Newman, H. H. Takei, and F. A. Carranza, Eds., pp. 229–244, W.B. Saunders, Philadelphia, Pa, USA, 9th edition, 2002. View at Google Scholar
  23. A. Pejcic, L. Kesic, Z. Brkic, Z. Pesic, and D. Mirkovic, “Effect of periodontal treatment on lipoproteins levels in plasma in patients with periodontitis,” Southern Medical Journal, vol. 104, no. 8, pp. 547–552, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. M. Gulati, V. Anand, N. Jain et al., “Essentials of periodontal medicine in preventive medicine,” International Journal of Preventive Medicine, vol. 4, no. 9, pp. 988–994, 2013. View at Google Scholar · View at Scopus
  25. R. S. Uppal, R. Bhandari, and K. Singh, “Association between erectile dysfunction and chronic periodontitis: a clinical study,” Indian Journal of Dental Research, vol. 25, no. 4, pp. 430–433, 2014. View at Publisher · View at Google Scholar · View at Scopus
  26. A. Sharma, A. R. Pradeep, and P. A. Raju, “Association between chronic periodontitis and vasculogenic erectile dysfunction,” Journal of Periodontology, vol. 82, no. 12, pp. 1665–1669, 2011. View at Publisher · View at Google Scholar · View at Scopus
  27. S. Matsumoto, M. Matsuda, M. Takekawa et al., “Association of ED with chronic periodontal disease,” International Journal of Impotence Research, vol. 26, no. 1, pp. 13–15, 2014. View at Publisher · View at Google Scholar · View at Scopus
  28. J. J. Keller, S.-D. Chung, and H.-C. Lin, “A nationwide population-based study on the association between chronic periodontitis and erectile dysfunction,” Journal of Clinical Periodontology, vol. 39, no. 6, pp. 507–512, 2012. View at Publisher · View at Google Scholar · View at Scopus
  29. C. W. Tsao, C. Y. Liu, T. L. Cha, S. T. Wu, S. C. Chen, and C. Y. Hsu, “Exploration of the association between chronic periodontal disease and erectile dysfunction from a population-based view point,” Andrologia, vol. 47, no. 5, pp. 513–518, 2015. View at Publisher · View at Google Scholar
  30. Y. Zadik, R. Bechor, S. Galor, D. Justo, and R. J. Heruti, “Erectile dysfunction might be associated with chronic periodontal disease: two ends of the cardiovascular spectrum,” The Journal of Sexual Medicine, vol. 6, no. 4, pp. 1111–1116, 2009. View at Publisher · View at Google Scholar · View at Scopus
  31. F. Oğuz, A. Eltas, A. Beytur, E. Akdemir, M. Ö. Uslu, and A. Güneş, “Is there a relationship between chronic periodontitis and erectile dysfunction?” The Journal of Sexual Medicine, vol. 10, no. 3, pp. 838–843, 2013. View at Publisher · View at Google Scholar · View at Scopus
  32. Z. Zuo, J. Jiang, R. Jiang et al., “Effect of periodontitis on erectile function and its possible mechanism,” Journal of Sexual Medicine, vol. 8, no. 9, pp. 2598–2605, 2011. View at Publisher · View at Google Scholar · View at Scopus
  33. K. A. Boggess, S. Lieff, A. P. Murtha, K. Moss, J. Beck, and S. Offenbacher, “Maternal periodontal disease is associated with an increased risk for preeclampsia,” Obstetrics and Gynecology, vol. 101, no. 2, pp. 227–231, 2003. View at Publisher · View at Google Scholar · View at Scopus
  34. F. Cairo, S. Castellani, A. M. Gori et al., “Severe periodontitis in young adults is associated with sub-clinical atherosclerosis,” Journal of Clinical Periodontology, vol. 35, no. 6, pp. 465–472, 2008. View at Publisher · View at Google Scholar · View at Scopus
  35. J. H. Behle, M. H. Sedaghatfar, R. T. Demmer et al., “Heterogeneity of systemic inflammatory responses to periodontal therapy,” Journal of Clinical Periodontology, vol. 36, no. 4, pp. 287–294, 2009. View at Publisher · View at Google Scholar · View at Scopus
  36. S. Amar, N. Gokce, S. Morgan, M. Loukideli, T. E. Van Dyke, and J. A. Vita, “Periodontal disease is associated with brachial artery endothelial dysfunction and systemic inflammation,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 23, no. 7, pp. 1245–1249, 2003. View at Publisher · View at Google Scholar · View at Scopus
  37. A. Blum, K. Kryuger, M. Mashiach Eizenberg et al., “Periodontal care may improve endothelial function,” European Journal of Internal Medicine, vol. 18, no. 4, pp. 295–298, 2007. View at Publisher · View at Google Scholar · View at Scopus
  38. G. D. Slade, S. Offenbacher, J. D. Beck, G. Heiss, and J. S. Pankow, “Acute-phase inflammatory response to periodontal disease in the US population,” Journal of Dental Research, vol. 79, no. 1, pp. 49–57, 2000. View at Publisher · View at Google Scholar · View at Scopus
  39. E. De Nardin, “The role of inflammatory and immunological mediators in periodontitis and cardiovascular disease,” Annals of Periodontology, vol. 6, no. 1, pp. 30–40, 2001. View at Publisher · View at Google Scholar · View at Scopus
  40. B. Noack, R. J. Genco, M. Trevisan, S. Grossi, J. J. Zambon, and E. De Nardin, “Periodontal infections contribute to elevated systemic C-reactive protien level,” Journal of Periodontology, vol. 72, no. 9, pp. 1221–1227, 2001. View at Publisher · View at Google Scholar · View at Scopus
  41. F. O. B. Correa, D. Gonçalves, C. M. S. Figueredo, A. Gustafsson, and S. R. P. Orrico, “The short-term effectiveness of non-surgical treatment in reducing levels of interleukin-1β and proteases in gingival crevicular fluid from patients with type 2 diabetes mellitus and chronic periodontitis,” Journal of Periodontology, vol. 79, no. 11, pp. 2143–2150, 2008. View at Publisher · View at Google Scholar · View at Scopus
  42. A. B. Navarro-Sanchez, R. Faria-Almeida, and A. Bascones-Martinez, “Effect of non-surgical periodontal therapy on clinical and immunological response and glycaemic control in type 2 diabetic patients with moderate periodontitis,” Journal of Clinical Periodontology, vol. 34, no. 10, pp. 835–843, 2007. View at Publisher · View at Google Scholar · View at Scopus
  43. K. V. Bhagat and P. Vallance, “Inflammatory cytokines impair endothelium-dependent dilatation in human veins in vivo,” Circulation, vol. 96, no. 9, pp. 3042–3047, 1997. View at Publisher · View at Google Scholar · View at Scopus
  44. T. Holm, P. Aukrust, A. K. Andreassen et al., “Peripheral endothelial dysfunction in heart transplant recipients: possible role of proinflammatory cytokines,” Clinical Transplantation, vol. 14, no. 3, pp. 218–225, 2000. View at Publisher · View at Google Scholar · View at Scopus
  45. C. Vlachopoulos, K. Aznaouridis, N. Ioakeimidis et al., “Unfavourable endothelial and inflammatory state in erectile dysfunction patients with or without coronary artery disease,” European Heart Journal, vol. 27, no. 22, pp. 2640–2648, 2006. View at Publisher · View at Google Scholar · View at Scopus
  46. F. Karadag, H. Ozcan, A. B. Karul, E. Ceylan, and O. Cildag, “Correlates of erectile dysfunction in moderate-to-severe chronic obstructive pulmonary disease patients,” Respirology, vol. 12, no. 2, pp. 248–253, 2007. View at Publisher · View at Google Scholar · View at Scopus
  47. S. Peng and D.-X. Zhang, “Chronic periodontal disease may be a sign for erectile dysfunction in men,” Medical Hypotheses, vol. 73, no. 5, pp. 859–860, 2009. View at Publisher · View at Google Scholar · View at Scopus
  48. S. A. Bokhari, A. Khan, W. Leung, and G. Wajid, “Association of periodontal and cardiovascular diseases: South-Asian studies 2001–2012,” Journal of Indian Society of Periodontology, vol. 19, no. 5, pp. 495–500, 2015. View at Publisher · View at Google Scholar
  49. C. M. Nguyen, J. W. Kim, V. H. Quan, B. H. Nguyen, and S. D. Tran, “Periodontal associations in cardiovascular diseases: the latest evidence and understanding,” Journal of Oral Biology and Craniofacial Research, vol. 5, no. 3, pp. 203–206, 2015. View at Publisher · View at Google Scholar
  50. M. S. Tonetti, F. D'Aiuto, L. Nibali et al., “Treatment of periodontitis and endothelial function,” The New England Journal of Medicine, vol. 356, no. 9, pp. 911–920, 2007. View at Publisher · View at Google Scholar · View at Scopus
  51. Y. Higashi, C. Goto, D. Jitsuiki et al., “Periodontal infection is associated with endothelial dysfunction in healthy subjects and hypertensive patients,” Hypertension, vol. 51, no. 2, pp. 446–453, 2008. View at Publisher · View at Google Scholar · View at Scopus
  52. Y. Higashi, C. Goto, T. Hidaka et al., “Oral infection-inflammatory pathway, periodontitis, is a risk factor for endothelial dysfunction in patients with coronary artery disease,” Atherosclerosis, vol. 206, no. 2, pp. 604–610, 2009. View at Publisher · View at Google Scholar · View at Scopus
  53. F. O. B. Correa, D. Gonçalves, C. M. S. Figueredo, A. S. Bastos, A. Gustafsson, and S. R. P. Orrico, “Effect of periodontal treatment on metabolic control, systemic inflammation and cytokines in patients with type 2 diabetes,” Journal of Clinical Periodontology, vol. 37, no. 1, pp. 53–58, 2010. View at Publisher · View at Google Scholar · View at Scopus
  54. A. B. Navarro-Sanchez, R. Faria-Almeida, and A. Bascones-Martinez, “Effect of non-surgical periodontal therapy on clinical and immunological response and glycaemic control in type 2 diabetic patients with moderate periodontitis,” Journal of Clinical Periodontology, vol. 34, no. 10, pp. 835–843, 2007. View at Publisher · View at Google Scholar · View at Scopus
  55. L. L. Haheim, I. Olsen, and K. S. Rønningen, “Association between tooth extraction due to infection and myocardial infarction,” Community Dentistry and Oral Epidemiology, vol. 39, no. 5, pp. 393–397, 2011. View at Publisher · View at Google Scholar · View at Scopus
  56. J. R. Kovac, C. Labbate, R. Ramasamy, D. Tang, and L. I. Lipshultz, “Effects of cigarette smoking on erectile dysfunction,” Andrologia, vol. 47, no. 10, pp. 1087–1092, 2015. View at Publisher · View at Google Scholar · View at Scopus
  57. R. Mazzilli, J. Elia, M. Delfino, F. Benedetti, G. Scordovillo, and F. Mazzilli, “Prevalence of diabetes mellitus (DM) in a population of men affected by erectile dysfunction (ED),” La Clinica Terapeutica, vol. 166, no. 5, pp. e317–e320, 2015. View at Google Scholar
  58. V. Phé and M. Rouprêt, “Erectile dysfunction and diabetes: a review of the current evidence-based medicine and a synthesis of the main available therapies,” Diabetes and Metabolism, vol. 38, no. 1, pp. 1–13, 2012. View at Publisher · View at Google Scholar · View at Scopus
  59. N. Katsiki, A. S. Wierzbicki, and D. P. Mikhailidis, “Erectile dysfunction and coronary heart disease,” Current Opinion in Cardiology, vol. 4, pp. 416–421, 2015. View at Publisher · View at Google Scholar