Plantago ovata F. Mucilage-Alginate Mucoadhesive Beads for Controlled Release of Glibenclamide: Development, Optimization, and In Vitro-In Vivo Evaluation

Table 1

Experimental plan of 3² factorial design (coded values in bracket) with observed response values for different glibenclamide-loaded IHM-alginate beads.

Batch code	Normalized levels of factors employed		Responses
	SA : IHM	CaCl2 concentration	DEE (%)*	𝑅10h (%)*
F-1	4 (+1)	10.00 (+1)	80.90±3.02	81.76±3.15
F-2	4 (+1)	7.50 (0)	72.31±2.79	88.23±3.17
F-3	4 (+1)	5.00 (−1)	68.03±2.32	92.07±4.05
F-4	2.50 (0)	10.00 (+1)	85.56±3.45	73.37±3.22
F-5	2.50 (0)	7.50 (0)	76.82±3.48	82.27±3.46
F-6	2.50 (0)	5.00 (−1)	72.44±2.87	88.00±3.84
F-7	1.00 (−1)	10.00 (+1)	92.33±3.82	66.22±2.51
F-8	1.00 (−1)	7.50 (0)	83.12±3.57	75.52±3.58
F-9	1.00 (−1)	5.00 (−1)	78.49±3.02	81.70±2.33

∗Mean ± S.D.; 𝑛=3.