Research Article
Artemether-Soluplus Hot-Melt Extrudate Solid Dispersion Systems for Solubility and Dissolution Rate Enhancement with Amorphous State Characteristics
Table 7
Florey Huggins modelling of prepared formulations.
| | Ratio | mix | pure | LHS | | | | | | 1/ | | | | log() | ln + 1 − 1/ | | (ln + 1 − 1/) | / | LHS | χ |
| | F1 | 0.012 | 0.01 | 0.0011 | 8.314 | 61.842 | −0.13 | 1 | 1 | 1 | 0 | 2 | 0 | 0 | 0 | 4 | 0 | −0.537755772 | 0.001084011 |
0.001084
| | F2 | 0.012 | 0.01 | 0.0011 | 8.314 | 61.842 | −0.13 | 1 | 2 | 0.5 | 0.5 | 3 | 1.5 | 0 | 1.5 | 9 | −0.201658414 | −1.209950487 | 0.001084011 | −0.16558 | | F3 | 0.012 | 0.01 | 0.0011 | 8.314 | 61.842 | −0.13 | 1 | 3 | 0.333333 | 0.6666667 | 4 | 2.666666667 | 0 | 2.666666667 | 16 | −0.358503848 | −2.151023088 | 0.001084011 | −0.16558 | | F4 | 0.013 | 0.01 | 0.0014 | 8.314 | 61.842 | −0.13 | 1 | 1 | 1 | 0 | 2 | 0 | 0 | 0 | 4 |
0
| −0.537755772 | 0.001388889 |
0.001389
| | F5 | 0.013 | 0.01 | 0.0014 | 8.314 | 61.842 | −0.13 | 1 | 2 | 0.5 | 0.5 | 3 | 1.5 | 0 | 1.5 | 9 | −0.201658414 | −1.209950487 | 0.001388889 | −0.16528 | | F6 | 0.013 | 0.01 | 0.0014 | 8.314 | 61.842 | −0.13 | 1 | 3 | 0.333333 | 0.6666667 | 4 | 2.666666667 | 0 | 2.666666667 | 16 | −0.358503848 | −2.151023088 | 0.001388889 | −0.16528 | | F7 | 0.013 | 0.01 | 0.0019 | 8.314 | 61.842 | −0.13 | 1 | 1 | 1 | 0 | 2 | 0 | 0 | 0 | 4 |
0
| −0.537755772 | 0.001875902 |
0.001876
| | F8 | 0.013 | 0.01 | 0.002 | 8.314 | 61.842 | −0.13 | 1 | 2 | 0.5 | 0.5 | 3 | 1.5 | 0 | 1.5 | 9 | −0.201658414 | −1.209950487 | 0.002046784 | −0.16462 | | F9 | 0.013 | 0.01 | 0.002 | 8.314 | 61.842 | −0.13 | 1 | 3 | 0.333333 | 0.6666667 | 4 | 2.666666667 | 0 | 2.666666667 | 16 | −0.358503848 | −2.151023088 | 0.002046784 | −0.16462 | | F10 | 0.012 | 0.01 | 0.0008 | 8.314 | 61.842 | −0.13 | 1 | 4 | 0.25 | 0.75 | 4 | 3 | 0 | 3 | 16 | −0.403316829 | −2.151023088 | 0.000793651 | −0.18671 | | F11 | 0.012 | 0.01 | 0.0008 | 8.314 | 61.842 | −0.13 | 1 | 5 | 0.2 | 0.8 | 5 | 4 | 0 | 4 | 25 | −0.537755772 | −3.360973575 | 0.000793651 | −0.15921 | | F12 | 0.012 | 0.01 | 0.0012 | 8.314 | 61.842 | −0.13 | 1 | 6 | 0.166667 | 0.8333333 | 6 | 5 | 0 | 5 | 36 | −0.672194715 | −4.839801948 | 0.001234568 | −0.13765 | | F13 | 0.012 | 0.01 | 0.0008 | 8.314 | 61.842 | −0.13 | 1 | 7 | 0.142857 | 0.8571429 | 7 | 6 | 0 | 6 | 49 | −0.806633658 | −6.587508206 | 0.000793651 | −0.12166 | | F14 | 0.012 | 0.01 | 0.0011 | 8.314 | 61.842 | −0.13 | 1 | 8 | 0.125 | 0.875 | 8 | 7 | 0 | 7 | 64 | −0.941072601 | −8.604092351 | 0.001084011 | −0.10829 | | F15 | 0.013 | 0.01 | 0.0015 | 8.314 | 61.842 | −0.13 | 1 | 9 | 0.111111 | 0.8888889 | 9 | 8 | 0 | 8 | 81 | −1.075511544 | −10.88955438 | 0.001547117 | −0.09722 |
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