Table of Contents Author Guidelines Submit a Manuscript
Journal of Pharmaceutics
Volume 2013, Article ID 381910, 10 pages
http://dx.doi.org/10.1155/2013/381910
Research Article

Some Pharmacodynamic Aspects of Cefepime

Pharmacology Department, Faculty of Veterinary Medicine, Benha University, P.O. Box 13736, Moshtohor, Toukh, Elqaliobiya, Egypt

Received 20 August 2012; Accepted 5 October 2012

Academic Editor: Mohammad A. Rashid

Copyright © 2013 Mossad Gamaleddin Ahmed Elsayed et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. C. Sanders, “Cefepime: the next generation?” Clinical Infectious Diseases, vol. 17, no. 3, pp. 369–379, 1993. View at Google Scholar · View at Scopus
  2. T. M. Chapman and C. M. Perry, “Cefepime: a review of its use in the management of hospitalized patients with pneumonia,” American Journal of Respiratory Medicine, vol. 2, no. 1, pp. 75–107, 2003. View at Google Scholar · View at Scopus
  3. S. S. Huang, S. C. Lee, N. Lee, L. C. See, M. H. Tsai, and W. B. Shieh, “Comparison of in vitro activities of levofloxacin, ciprofloxacin, ceftazidime, cefepime, imipenem, and piperacillin-tazobactam against aerobic bacterial pathogens from patients with nosocomial infections,” Journal of Microbiology, Immunology and Infection, vol. 40, no. 2, pp. 134–140, 2007. View at Google Scholar · View at Scopus
  4. D. Yahav, M. Paul, A. Fraser, N. Sarid, and L. Leibovici, “Efficacy and safety of cefepime: a systematic review and meta-analysis,” Lancet Infectious Diseases, vol. 7, no. 5, pp. 338–348, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. J. L. Crandon, J. L. Kuti, R. N. Jones, and D. P. Nicolau, “Comparison of 2002-2006 OPTAMA programs for US hospitals: focus on gram-negative resistance,” Annals of Pharmacotherapy, vol. 43, no. 2, pp. 220–227, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. P. Valeri, B. Martinelli, L. A. Morrone, and C. Severini, “Reproducible withdrawal contractions of isolated guinea-pig ileum after brief morphine exposure: effects of clonidine and nifedipine,” Journal of Pharmacy and Pharmacology, vol. 42, no. 2, pp. 115–120, 1990. View at Google Scholar · View at Scopus
  7. Members of the Departement of Pharmacology, University of Edinburgh, Pharmacological Experiments on Isolated Preparation, Churchill-Livingstone, Edinburgh, UK, 2nd edition, 1968.
  8. K. Milenov and R. Kalfin, “Cholinergic-nitrergic interactions in the guinea-pig gastric fundus,” Neuropeptides, vol. 30, no. 4, pp. 365–371, 1996. View at Publisher · View at Google Scholar · View at Scopus
  9. V. Schlemper and J. B. Calixto, “Mechanisms involved in the relaxant response of bradykinin in epithelium intact strips of the guinea-pig trachea,” European Journal of Pharmacology, vol. 282, no. 1-3, pp. 177–184, 1995. View at Publisher · View at Google Scholar · View at Scopus
  10. R. B. Barlow, T. B. B. Crawford, and W. L. M. Perry, Pharmacological Experiments on Isolated Preparations, Churchill Livingstone, New York, NY, USA, 1974.
  11. E. Bulbring, “Observation on the isolated rat phrenic nerve diaphragm preparation,” British Journal of Pharmacology and Chemotherapy, vol. 1, pp. 38–61, 1946. View at Google Scholar
  12. C. M. L. Vasconcelos, M. S. Araújo, B. A. Silva, and E. A. Conde-Garcia, “Negative inotropic and chronotropic effects on the guinea pig atrium of extracts obtained from Averrhoa carambola L. leaves,” Brazilian Journal of Medical and Biological Research, vol. 38, no. 7, pp. 1113–1122, 2005. View at Google Scholar · View at Scopus
  13. L. M. Hondeghem and P. Hoffmann, “Blinded test in isolated female rabbit heart reliably identifies action potential duration prolongation and proarrhythmic drugs: importance of triangulation, reverse use dependence, and instability,” Journal of Cardiovascular Pharmacology, vol. 41, no. 1, pp. 14–24, 2003. View at Publisher · View at Google Scholar · View at Scopus
  14. D. E. Jackson, Experimental Pharmacology and Materia Media, Hynry. Kympton, London, UK, 1st edition, 1939.
  15. A. Takai, S. Hirai, I. Watanabe et al., “General pharmacology of cefoperazone, a new cephalosporin antibiotic,” Japanese Journal of Antibiotics, vol. 33, no. 10, pp. 994–1018, 1980. View at Google Scholar · View at Scopus
  16. Y. Yamaki, Y. Shibazaki, H. Kadosaka et al., “Pharmacological studies on a new cephamycin, MT-141. (2) Its effect on preparations of neuromuscular junction, smooth muscle organs and gastro-intestinal system,” Japanese Journal of Antibiotics, vol. 37, no. 8, pp. 1470–1487, 1984. View at Google Scholar · View at Scopus
  17. M. G. Elsayed, A. A. Elkomy, and M. H. Aboubakr, “Effect of ceftriaxone on isolated smooth, cardiac muscles and neuromuscular junctions,” International Journal for Agro Veterinary and Medical Sciences, vol. 5, no. 2, pp. 138–151, 2011. View at Google Scholar
  18. Y. Hasegawa, N. Muto, and M. Morita, “General pharmacology of cefadroxil,” Japanese Journal of Antibiotics, vol. 32, no. 12, pp. 1356–1371, 1979. View at Google Scholar · View at Scopus
  19. F. Honda, T. Ono, and N. Itoh, “General pharmacology of ceftizoxime sodium,” Drug Research, vol. 30, no. 10, pp. 1680–1687, 1980. View at Google Scholar · View at Scopus
  20. A. Takai, S. Hirai, and I. Watanabe, “General pharmacology of T-1982, a new cephamycin antibiotic,” Japanese Journal of Antibiotics, vol. 35, no. 9, pp. 2139–2154, 1982. View at Google Scholar
  21. A. Goto, M. Amano, A. Sakai, M. Hara, and N. Takahashi, “General pharmacology of cefprozil,” Japanese Journal of Antibiotics, vol. 43, no. 7, pp. 1289–1308, 1990. View at Google Scholar · View at Scopus
  22. A. Goto, M. Amano, A. Sakai, M. Hara, and N. Takahashi, “General pharmacology of cefepime,” Japanese Journal of Antibiotics, vol. 45, no. 6, pp. 661–680, 1992. View at Google Scholar · View at Scopus
  23. M. G. A. El-Sayed, M. R. Hassanin, M. H. Hafez, A. A. A. El-Komy, and A. Mohamed, “Some pharmacodynamic and biochemical aspects of cefamandole,” Deutsche Tierarztliche Wochenschrift, vol. 104, no. 11, pp. 481–487, 1997. View at Google Scholar · View at Scopus
  24. C. Ceran, B. Karadas, T. Kaya, M. Arpacik, I. Bagcivan, and B. Sarac, “Do antibiotics contribute to postoperative ileus? Contractile responses of ileum smooth muscle in guinea pigs to long-term parenteral ceftriaxone and ampicillin,” ANZ Journal of Surgery, vol. 76, no. 11, pp. 1023–1026, 2006. View at Publisher · View at Google Scholar · View at Scopus
  25. S. M. Janković, D. Kouvelas, and M. Mitrović, “Spasmogenic action of beta-lactam antibiotics an the gastrointestinal tract of experimental animals,” Indian Journal of Medical Research, vol. 104, pp. 216–222, 1996. View at Google Scholar · View at Scopus
  26. S. Hirai, T. Kodama, and T. Hiraiwa, “General pharmacology of cefteram pivoxil, a new oral cephem antibiotic,” Japanese Journal of Antibiotics, vol. 39, no. 4, pp. 958–978, 1986. View at Google Scholar
  27. S. Kai, H. Kohmura, K. Ishikawa et al., “Reproductive and developmental toxicity studies on cefepime dihydrochloride adminstered subcutaneously to rats during the premating, gestation and lactation periods,” Japanese Journal of Antibiotics, vol. 45, no. 6, pp. 642–660, 1992. View at Google Scholar · View at Scopus
  28. R. P. Rubin, “The role of calcium in the release of neurotransmitter substances and hormones,” Pharmacological Reviews, vol. 22, no. 3, pp. 389–428, 1970. View at Google Scholar · View at Scopus
  29. A. M. Katz and D. I. Repke, “Calcium-membrane interactions in the myocardium: effects of ouabain, epinephrine and 3′, 5′-cyclic adenosine monophosphate,” The American Journal of Cardiology, vol. 31, no. 2, pp. 193–201, 1973. View at Google Scholar · View at Scopus
  30. M. Kurebe, H. Asaoka, and Y. Yamaki, “Pharmacological studies on a new cephamycin, MT-141. (1) Its effect on central nervous system, respiration and cardiovascular system,” Japanese Journal of Antibiotics, vol. 37, no. 7, pp. 1428–1439, 1984. View at Google Scholar · View at Scopus