Some Pharmacodynamic Aspects of Cefepime

Table 2

The effect of cefepime on isolated guinea pig's auricles, rabbit's heart, and rabbit's aortic strip.

Concentrations (μg/mL bath)	Responses of
	Guinea pig's auricles	Rabbit's heart	Rabbit's aortic strip
0.0125	No effect	No effect	No effect
5	No effect	No effect	No effect
10	No effect	No effect	No effect
20	No effect	No effect	No effect
40	No effect	No effect	No effect
60	No effect	No effect	No effect
80	No effect	No effect	No effect
100	No effect	Slight negative inotropic effect.	No effect
200	Slight negative inotropic effect.	Slight negative inotropic effect.	No effect
400	Slight negative inotropic effect.	Slight negative inotropic effect.	No effect
800	Marked negative inotropic effect	Marked negative inotropic effect	No effect