Some Pharmacodynamic Aspects of Cefepime

Table 3

Effect of single intramuscular injection of 93.33 mg/kg body weight of cefepime on electrocardiographic changes in conscious rabbits (𝑛=3).

ECG parameters	Time (hours)
	0	0.25	0.5	1	2	4	8
P-wave:
(a) Amplitude (m·v.)	0.15 ± 0.0	0.15 ± 0.0	0.15 ± 0.0	0.15 ± 0.0	0.15 ± 0.0	0.15 ± 0.0	0.15 ± 0.0
(b) Duration (m·sec.)	38.66 ± 0.67	34 ± 0.58	34 ± 1.15	37.66 ± 1.45	36.33 ± 0.88	37.67 ± 0.33	40 ± 0.0
PR-interval: (m·sec.)	20 ± 0.0	20 ± 0.0	20 ± 0.0	20 ± 0.0	20 ± 0.0	20 ± 0.0	20 ± 0.0
QRS-complex:
(a) Amplitude (m·v.)	0.53 ± 0.033	0.43 ± 0.02	0.53 ± 0.017	0.53 ± 0.033	0.57 ± 0.033	0.43 ± 0.02	0.55 ± 0.003
(b) Duration (m·sec.)	20 ± 0.0	20 ± 0.0	20 ± 0.0	20 ± 0.0	20 ± 0.0	20 ± 0.0	20 ± 0.0
ST-segment: (m·sec.)	40 ± 0.0	40 ± 0.0	40 ± 0.0	40 ± 0.0	40 ± 0.0	40 ± 0.0	40 ± 0.0
T-wave
(a) Amplitude (m·v.)	0.19 ± 0.007	0.16 ± 0.007	0.15 ± 0.0	0.19 ± 0.007	0.20 ± 0.0	0.19 ± 0.007	0.20 ± 0.0
(b) Duration (m·sec.)	40 ± 0.0	42 ± 1	42 ± 1	39.33 ± 0.67	40 ± 0.0	40.67 ± 0.67	40 ± 0.0
QT-interval: (m·sec.)	140 ± 1.16	136.3 ± 0.88	135 ± 0.0	138 ± 1.15	140.67 ± 0.67	142.3 ± 1.45	142.3 ± 1.45
H.R: (beets/min)	300 ± 0.0	300 ± 0.0	300 ± 0.0	300 ± 0.0	300 ± 0.0	300 ± 0.0	300 ± 0.0