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Journal of Pharmaceutics
Volume 2013, Article ID 390425, 5 pages
Research Article

Buckysomes: New Nanocarriers for Anticancer Drugs

1Division of Cardiology, Department of Internal Medicine, The University of Texas Health Science Center at Houston, 1881 East Road, Houston, TX 77054, USA
2Biomatrica, 5627 Oberlin Drive, San Diego, CA 92121, USA
3Graduate Schools of Biomedical Sciences, The University of Texas Health Science Center at Houston, 6767 Bertner Ave, Houston, TX 77030, USA
4Department of Anesthesiology, The University of Texas Health Science Center at Houston, 6431 Fannin Street, Houston, TX 7703, USA
5Casscells & Associates, LLC, 7111 Davis Court, McLean, VA 22101, USA

Received 28 November 2012; Accepted 1 February 2013

Academic Editor: Awesh Yadav

Copyright © 2013 Delia Danila et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

A detailed description of the methods used for the extraction of Abraxane/Paclitaxel/AF-1 from various organs and the HPLC analysis of Abraxane, AF-1, and paclitaxel after extraction from organs is presented in the Supplementary Material. Details on abraxane/paclitaxel extraction efficiency measurements are also provided.

The organ biodistribution of paclitaxel in paclitaxel-embedded buckysomes and AF-1 in empty buckysomes at 15, 30, 45, 60, and 180 minutes after tail vein injection in ICR mice is presented in the Supplementary Material in order to support the conclusion that paclitaxel was successfully encapsulated in the hydrophobic interior of buckysomes.

  1. Supplementary Materials