Research Article

Optimization of Carboxymethyl-Xyloglucan-Based Tramadol Matrix Tablets Using Simplex Centroid Mixture Design

Table 3

Coded levels and their corresponding actual values of ingredients.

CodedActual values
level Carboxymethyl xyloglucanHPMC (K100M)DCP

01801030
0.33186.6716.6736.67
0.51902040
12003050

All quantities in mg.