Research Article
Optimization of Carboxymethyl-Xyloglucan-Based Tramadol Matrix Tablets Using Simplex Centroid Mixture Design
Table 4
Composition of
to
formulations.
| | Ingredients | Formulations (mg) | | | | | | | |
| | Tramadol HCl | 100 | 100 | 100 | 100 | 100 | 100 | 100 | | Carboxymethyl xyloglucan | 200 | 180 | 180 | 190 | 190 | 180 | 186.67 | | HPMC-k-100M | 10 | 30 | 10 | 20 | 10 | 20 | 16.67 | | DCP | 30 | 30 | 50 | 30 | 40 | 40 | 36.67 | | Talc | 5 | 5 | 5 | 5 | 5 | 5 | 5 | | Magnesium stearate | 5 | 5 | 5 | 5 | 5 | 5 | 5 | | PVP K-30 | 30 | 30 | 30 | 30 | 30 | 30 | 30 | | Isopropyl alcohol | qs. | qs. | qs. | qs. | qs. | qs. | qs. |
| | Total | 380 | 380 | 380 | 380 | 380 | 380 | 380 |
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All quantities in mg.
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